Evidence of endothelial dysfunction in the development of Alzheimer's disease : Is Alzheimer's a vascular disorder?

Acknowledgements Dr Soiza is funded by an NRS Career Research Fellowship. The authors are grateful to Alzheimer’s Research UK for providing funding.Peer reviewedPublisher PD

A follow-up study of the 1951-1955 business graduates of the Attleboro High School, Attleboro, Massachusetts

Thesis (Ed.M.)--Boston UniversityThe purposes ef this thesis were to determine how well the present business pregram prepared the graduates for their work and to obtain information which might be helpful in improving the business education program by making a follow-up study of the 1950-1954 business graduates of the Attleboro High School

A comparison of pilot-scale supersonic direct steam injection to conventional steam infusion and tubular heating systems for the heat treatment of protein-enriched skim milk-based beverages

peer-reviewedDirect supersonic steam injection, direct steam infusion, and indirect tubular heating were each applied to protein-enriched skim milk-based beverages with 4, 6 and 8% (w/w) total protein, and the effect of final heat temperature on the physical properties of these beverages was investigated. Supersonic steam injection resulted in significantly lower levels of denaturation of β-lactoglobulin (34.5%), compared to both infusion (76.3%) and tubular (97.1%) heating technologies. Viscosity, particle size and accelerated physical stability of formulations did not differ significantly between the heating technologies, while noticeable colour differences due to heat treatment (mainly attributed to increasing b* value) were observed, particularly for tubular heating. Overall, the extent of protein denaturation in high-protein dairy products was significantly influenced by the particular heating technology applied. The application of supersonic steam injection technology, with rapid heating and high shear characteristics, may enable differenciated product characteristics for ready-to-drink ambient-delivery high-protein dairy beverages. Industrial relevance: The design and application of novel direct supersonic steam injection technology was comprehensively studied and found to provide significant benefits over direct steam infusion and indirect tubular heating technologies for skim milk-based protein beverages. This type of injection heating system resulted in heat-treated formulations with lower levels of denatured whey proteins, compared to tubular and infusion heating, offering an alternative opportunity to the industry in terms of producing shelf-stable dairy protein beverages

Dominating cliques in graphs

AbstractA set of vertices is a dominating set in a graph if every vertex not in the dominating set is adjacent to one or more vertices in the dominating set. A dominating clique is a dominating set that induces a complete subgraph. Forbidden subgraph conditions sufficient to imply the existence of a dominating clique are given. For certain classes of graphs, a polynomial algorithm is given for finding a dominating clique. A forbidden subgraph characterization is given for a class of graphs that have a connected dominating set of size three

Schumpeter's Bahnbrechen considered in the light of Native Title Legislation and Indigenous entrepreneurship

In Australia, the Native Title Act 1993 (NTAct) dramatically altered the business and property environment, constituting a Bahnbrechen or transformative regulatory change which created the benefit of native title recognition for Aboriginals. This Study provides an account of NTAct’s operation and many negative elements, along with its intriguingly positive impact upon entrepreneurial opportunity. It shows that the simple fact of the chaotic setting of a transformative regulatory change shakes things up in a way that impacts upon entrepreneurial opportunity, even while its policies are anti-entrepreneurial and disempowering

The Repressors of mTORC1 Signaling, REDD1 and REDD2, Are Induced in Immobilized Rat Skeletal Muscle

Please view abstract in the attached PDF file

Characterization of best linear unbiased estimates generated from national genetic evaluations of reproductive performance, survival, and milk yield in dairy cows

peer-reviewedGenetic evaluations decompose an observed phenotype into its genetic and nongenetic components; the former are termed BLUP with the solutions for the systematic environmental effects in the statistical model termed best linear unbiased estimates (BLUE). Geneticists predominantly focus on the BLUP and rarely consider the BLUE. The objective of this study, however, was to define and quantify the association between 8 herd-level characteristics and BLUE for 6 traits in dairy herds, namely (1) age at first calving, (2) calving to first service interval (CFS), (3) number of services, (4) calving interval (CIV), (5) survival, and (6) milk yield. Phenotypic data along with the fixed and random effects solutions were generated from the Irish national multi-breed dairy cow fertility genetic evaluations on 3,445,557 cows; BLUE for individual contemporary groups were collapsed into mean herd-year estimates. Data from 5,707 spring-calving herds between the years 2007 and 2016 inclusive were retained; association analyses were undertaken using linear mixed multiple regression models. Pearson coefficient correlations were used to quantify the relationships among individual trait herd-year BLUE, and transition matrices were used to understand the dynamics of mean herd BLUE estimates over years. Based on the mean annual trends in raw, BLUP, and BLUE, it was estimated that BLUE were associated with at least two-thirds of the improvement in CIV and milk production over the past 10 yr. Milk recording herds calved heifers for the first time on average 15 d younger, had an almost 2 d longer CFS but 2.3 d shorter CIV than non-milk-recording herds. Larger herd sizes were associated with worse BLUE for both CFS and CIV. Expanding herds and herds that had the highest proportion of cows born on the farm itself, on average, calved heifers younger and had shorter CIV. By separating the raw performance of a selection of herds into their respective BLUE and BLUP, it was possible to identify herds with inferior management practices that were being compensated by superior genetics; similarly, herds were identified with superior BLUE, but because of their inferior genetic merit, were not reaching their full potential. This suggests that BLUE could have a pivotal role in a tailored decision support tool that would enable producers to focus on the most limiting factor hindering them from achieving their maximum performance

Research impact: an institutional logics perspective of related tensions in higher education.

The UK Higher Education sector’s emphasis on research “impact” (economic, social, environmental and cultural benefits) leads to tensions which academics are often ill-equipped to navigate. Our understanding of such tensions is largely limited by a narrow empirical focus on knowledge commercialisation and oversimplified conceptualisations of the underlying process of change. This study employs an exploratory, holistic multiple case design to explore tensions experienced by 30 business and management scholars and participants in the 2014 Research Excellence Framework (REF2014), the first national evaluation of research impact globally. It deploys institutional logics as a conceptual lens as this is underpinned by a theory of action (embedded agency) offering greater explanatory power for how macro- and meso-level factors influence micro level behaviour than alternatives predominantly used in existing explorations of impact. Six major findings regarding individual level impact-related tensions are reported at the ‘individual’ level of analysis. First, three novel tensions were identified. Second, eight conceptual tensions were empirically observed. Third, certain tensions are underpinned by forms of embeddedness not currently associated with the institutional logics perspective. Fourth, most of the identified tensions are not associated with an often alluded to professional- market logics dualism, but with various configurations of five logics. Fifth, certain tensions are associated with a single, professional logic. Sixth, strategic responses to certain tensions are typically generative of impactful research, although occasionally defensive responses can also be generative. Three theoretical contributions are proposed. First, the empirical confirmation of a typology of individual-level impact-related tensions, within which three novel tensions are identified. Second, the development of the logics perspective through revelation of new types of embeddedness as theories of change and third; the conceptualisation of institutional monism as an alternative source of conflicting logics to institutional pluralism. Finally, a contribution to professional research practice is also made in recommending that barriers to research effectiveness should be responded to strategically rather than defensively in order to maximise impact generation.PhD in Leadership and Managemen